Foxp3 drives oxidative phosphorylation and protection from lipotoxicity
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چکیده
منابع مشابه
Foxp3 drives oxidative phosphorylation and protection from lipotoxicity.
Tregs can adopt a catabolic metabolic program with increased capacity for fatty acid oxidation-fueled oxidative phosphorylation (OXPHOS). It is unclear why this form of metabolism is favored in Tregs and, more specifically, whether this program represents an adaptation to the environment and developmental cues or is "hardwired" by Foxp3. Here we show, using metabolic analysis and an unbiased ma...
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It has been claimed that barbiturates uncouple oxidative phosphorylations (Brody & Bain, 1954; Brody, 1955). These authors have demonstrated that during the oxidation of pyruvate by liver and brain mitochondria, phosphate uptake was lowered proportionately more than oxygen uptake. Support for the uncoupling theory was derived from certain similarities between the barbiturates and 2:4dinitrophen...
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37 Karpinksi. S. (1994) I’h.1). Thesis. Swedish University of Agricultural Sciences. limea Greer. S. and I’erham, K. N. (1986) Biochemistry 25. 2736-2742 Kunert, K. J., Cresswell. C. F., Schmidt. A.. Mullineaux, 1’. M. and Foyer, C. H. (1990) Arch. Hiochem. Hiophys. 282.233-238 Foyer. C. H.. Lelandais. M., Galap, C. and Kunert, K. J. (1991) I’lant I’hysiol. 97.803-872 Aono. M., Kubo. A., Saji9 ...
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OBJECTIVE Alternative activation (M2) of adipose tissue resident macrophage (ATM) inhibits obesity-induced metabolic inflammation. The underlying mechanisms remain unclear. Recent studies have shown that dysregulated lipid homeostasis caused by increased lipolysis in white adipose tissue (WAT) in the obese state is a trigger of inflammatory responses. We investigated the role of M2 macrophages ...
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1. Oxidative phosphorylation was studied in a cell-free preparation of Mycobacterium phlei and in rat-liver mitochondria. Phosphorylation was destroyed in both systems by long-wave ultraviolet radiation and restored by the addition of small amounts of [2-Me-(14)C,(3)H]phylloquinone. When the radioactive quinones were recovered from the phosphorylating system and chromatographed with carrier phy...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2017
ISSN: 2379-3708
DOI: 10.1172/jci.insight.89160